Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc
Journal website https://jnr.elmerpub.com

Case Report

Volume 15, Number 4, December 2025, pages 203-210


Multifocal Bihemispheric Ischemic Strokes Due to Unknown Thrombotic Microangiopathy

Figures

Figure 1.
Figure 1. Magnetic resonance imaging (MRI) of the brain, axial T2-weighted fluid-attenuated inversion recovery (FLAIR) sequences. Red arrows indicate areas of persistent hyperintensity consistent with evolving acute ischemic infarcts in the bilateral cerebral hemispheres, notably involving the frontal, parietal, and periventricular white matter regions. Additional foci in the right frontal and parietal lobes suggest new acute infarcts. Confluent periventricular hyperintensities are present, compatible with moderate chronic microvascular ischemic disease. Red arrowheads highlight areas of subacute-to-chronic ischemic injury/encephalomalacia, demonstrated by parenchymal volume loss and gliotic signal in the bilateral occipital lobes and right parietal lobe. Multiple small chronic lacunar infarcts are also seen in the corona radiata and centrum semiovale.
Figure 2.
Figure 2. Computed tomography (CT) of the brain (axial non-contrast). Green arrows indicate a worsening leftward midline shift, now measuring approximately 12 mm (previously 7 - 8 mm), due to significant hemispheric mass effect. Yellow arrow highlights hypodensity and swelling in the brainstem and cerebellum, consistent with acute cerebral edema. Red arrow denotes acute subarachnoid hemorrhage within the basal cisterns and right-sided cerebral sulci. Chronic ischemic changes, characterized by volume loss and gliosis in the right occipital lobe and left cerebral hemisphere, would be marked with blue arrowheads for distinction from acute pathology.
Figure 3.
Figure 3. Dual-energy computed tomography (DECT) of the head (axial view). Red arrow indicates a large area of hypodensity involving the right cerebral hemisphere, associated with pronounced mass effect and midline shift, consistent with an extensive acute-to-subacute ischemic infarct. No subarachnoid hemorrhage is seen. Red arrowhead marks an area of chronic ischemic injury/encephalomalacia in the left occipital region, characterized by parenchymal volume loss and gliosis. The use of arrowheads differentiates chronic lesions from acute/subacute pathology.

Table

Table 1. Hematologic, Biochemical, and Coagulation Parameters After Thrombectomy
 
LaboratoryNormal rangePost-NIR3 h post-NIR4 h post-NIR9 h post-NIR11 h post-NIR13 h post-NIR
INR: international normalized ratio; BUN: blood urea nitrogen; CR: creatinine; MCV: mean corpuscular volume; NIR: neurointerventional radiology; HPF: high-power field.
Hemoglobin (g/dL)12 - 165.05.05.06.77.38.2
Hematocrit (%)36 - 4616.216.5-21.623.424.0
Platelets (× 103/µL)130 - 40044--58-
INR0.9 - 1.2--3.6-2.6-
Prothrombin time (s)11.3 - 14.7--34.0-26.4-
Fibrinogen (mg/dL)214 - 481< 60-177---
SchistocytesNot present-Present (< 1 schistocyte/HPF)---
BUN (mg/dL)10 - 25435356-62-
Cr (mg/dL)0.70 - 1.402.22.62.9-3.5-
BUN/Cr ratio12 - 2019.5520.3819.31-17.71-
Total bilirubin (mg/dL)< 1.21.9-4.4-4.7-
Indirect bilirubin (mg/dL)< 1.01.1-3.1-3.4-
MCV (fL)80 - 100-80.1--81.5-