J Neurol Res

Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc

Journal website https://jnr.elmerpub.com

Original Article

Volume 16, Number 2, June 2026, pages 77-87

Comparison of Diffusion Tensor Imaging Parameters Associated With Motor Fiber Injury Between Patients With Chronic Subdural Hematoma and Intracerebral Hemorrhage

↓ Figure 1. Method for setting the region of interest (ROI): (a) precentral gyrus; (b) posterior limb of the internal capsule; (c) cerebral peduncle.

↓ Figure 2. Comparative fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values between the lesion and normal hemisphere in patients with chronic subdural hematoma (CSDH).

↓ Figure 3. Comparative diffusion tensor imaging (DTI) parameters between the lesion and normal hemisphere in patients with intracerebral hemorrhage (ICH).

↓ Figure 4. Comparison of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values among chronic subdural hematoma (CSDH), intracerebral hemorrhage (ICH), and healthy control groups. Bars indicate means, and error bars represent standard deviations. Statistical comparisons are performed using the Tukey–Kramer method for multiple group comparisons. Additionally, pairwise comparisons between the chronic subdural hematoma (CSDH) and intracerebral hemorrhage (ICH) groups are conducted using the unpaired t-test for fractional anisotropy (FA) and the Mann–Whitney U test for apparent diffusion coefficient (ADC).

↓ Figure 7. Correlation between lesion fractional anisotropy (FA) value and modified Rankin scale (mRS) score at discharge.

↓ **Table 1.** The FA and ADC Values Pre- and Post-Surgery in Patients With CSDH (ADC: × 10^-3 mm²/s)
Patient	Pre-surgery	Post-surgery
ADC: apparent diffusion coefficient; CSDH: chronic subdural hematoma; FA: fractional anisotropy.
1	0.542	0.524	0.664	0.736	0.564	0.548	0.657	0.713
2	0.631	0.608	0.68	0.687	0.513	0.524	0.722	0.701
3	0.552	0.524	0.68	0.712	0.546	0.524	0.729	0.768
4	0.534	0.517	0.74	0.727	0.522	0.517	0.74	0.727
5	0.49	0.513	0.661	0.757	0.524	0.523	0.684	0.769
6	0.566	0.544	0.709	0.724	0.594	0.54	0.646	0.713
7	0.57	0.552	0.664	0.721	0.519	0.541	0.69	0.682
8	0.519	0.579	0.728	0.722	0.571	0.579	0.735	0.74
9	0.539	0.52	0.741	0.725	0.512	0.51	0.784	0.871
10	0.493	0.504	0.687	0.703	0.54	0.524	0.709	0.744
11	0.543	0.532	0.626	0.685	0.529	0.529	0.697	0.68
12	0.6	0.562	0.733	0.718
13	0.524	0.515	0.689	0.741
14	0.597	0.565	0.65	0.654
15	0.604	0.496	0.704	0.884
16	0.585	0.565	0.658	0.676
17	0.483	0.48	0.775	0.81
18	0.562	0.547	0.728	0.72
19	0.495	0.533	0.656	0.736
20	0.556	0.557	0.739	0.762
21	0.65	0.642	1.04	0.974
22	0.552	0.514	0.731	0.701
23	0.616	0.603	0.672	0.645
24	0.546	0.575	0.638	0.656
25	0.448	0.5	0.784	0.809
26	0.554	0.564	0.674	0.664
27	0.573	0.567	0.642	0.701
28	0.524	0.532	0.842	0.789
29	0.558	0.58	0.666	0.689

↓ Table 1. The FA and ADC Values Pre- and Post-Surgery in Patients With CSDH (ADC: × 10^-3 mm²/s)

Patient

Pre-surgery

Post-surgery

ADC

Lesion

Normal

Lesion

Normal

Lesion

Normal

Lesion

Normal

ADC: apparent diffusion coefficient; CSDH: chronic subdural hematoma; FA: fractional anisotropy.

0.542

0.524

0.664

0.736

0.564

0.548

0.657

0.713

0.631

0.608

0.68

0.687

0.513

0.524

0.722

0.701

0.552

0.524

0.68

0.712

0.546

0.524

0.729

0.768

0.534

0.517

0.74

0.727

0.522

0.517

0.74

0.727

0.49

0.513

0.661

0.757

0.524

0.523

0.684

0.769

0.566

0.544

0.709

0.724

0.594

0.54

0.646

0.713

0.57

0.552

0.664

0.721

0.519

0.541

0.69

0.682

0.519

0.579

0.728

0.722

0.571

0.579

0.735

0.74

0.539

0.52

0.741

0.725

0.512

0.51

0.784

0.871

0.493

0.504

0.687

0.703

0.54

0.524

0.709

0.744

0.543

0.532

0.626

0.685

0.529

0.697

0.68

0.6

0.562

0.733

0.718

0.524

0.515

0.689

0.741

0.597

0.565

0.65

0.654

0.604

0.496

0.704

0.884

0.585

0.565

0.658

0.676

0.483

0.48

0.775

0.81

0.562

0.547

0.728

0.72

0.495

0.533

0.656

0.736

0.556

0.557

0.739

0.762

0.65

0.642

1.04

0.974

0.552

0.514

0.731

0.701

0.616

0.603

0.672

0.645

0.546

0.575

0.638

0.656

0.448

0.5

0.784

0.809

0.554

0.564

0.674

0.664

0.573

0.567

0.642

0.701

0.524

0.532

0.842

0.789

0.558

0.58

0.666

0.689

↓ **Table 2.** Comparison of DTI Parameters According to ICH Lesion Location (ADC: × 10^-3 mm²/s)
Patient	Putamen (n = 13)	Subcortical (n = 11)	Thalamus (n = 13)
Putamen (mean 69.5 ± 12.1 years; eight men and five women), subcortical (mean 71.2 ± 12.3 years; five men and six women), thalamus (mean 75.2 ± 15.4 years; five men and eight women). Each lesion location represents a distinct patient. No patient had multiple hemorrhage locations. ADC: apparent diffusion coefficient; FA: fractional anisotropy; ICH: intracerebral hemorrhage.
1	0.474	0.543	0.939	0.799	0.486	0.501	0.732	0.713	0.507	0.524	0.739	0.712
2	0.515	0.504	0.818	0.893	0.543	0.531	0.733	0.836	0.5	0.516	0.693	0.791
3	0.472	0.494	0.812	0.858	0.531	0.516	0.616	0.746	0.596	0.534	0.75	0.768
4	0.491	0.521	0.843	0.921	0.531	0.536	0.744	0.854	0.523	0.551	0.794	0.774
5	0.516	0.554	0.659	0.681	0.587	0.53	0.716	0.729	0.566	0.625	0.605	0.591
6	0.543	0.531	0.733	0.836	0.54	0.549	0.661	0.651	0.503	0.502	0.695	0.764
7	0.506	0.491	0.773	0.818	0.532	0.511	0.769	0.732	0.52	0.551	0.794	0.767
8	0.462	0.494	0.589	0.722	0.568	0.597	0.766	0.875	0.503	0.48	0.766	0.857
9	0.573	0.61	0.81	0.813	0.533	0.5	0.713	0.787	0.534	0.505	0.774	0.7
10	0.482	0.511	0.72	0.823	0.595	0.601	0.498	0.695	0.491	0.506	0.729	0.787
11	0.514	0.522	0.741	0.819	0.486	0.518	0.613	0.656	0.515	0.515	0.776	0.767
12	0.483	0.531	0.704	0.797	0.523	0.55	0.578	0.647
13	0.549	0.527	0.643	0.684	0.551	0.567	0.731	0.71

↓ Table 2. Comparison of DTI Parameters According to ICH Lesion Location (ADC: × 10^-3 mm²/s)

Patient

Putamen (n = 13)

Subcortical (n = 11)

Thalamus (n = 13)

ADC

Lesion

Normal

Lesion

Normal

Lesion

Normal

Lesion

Normal

Lesion

Normal

Lesion

Normal

Putamen (mean 69.5 ± 12.1 years; eight men and five women), subcortical (mean 71.2 ± 12.3 years; five men and six women), thalamus (mean 75.2 ± 15.4 years; five men and eight women). Each lesion location represents a distinct patient. No patient had multiple hemorrhage locations. ADC: apparent diffusion coefficient; FA: fractional anisotropy; ICH: intracerebral hemorrhage.

0.474

0.543

0.939

0.799

0.486

0.501

0.732

0.713

0.507

0.524

0.739

0.712

0.515

0.504

0.818

0.893

0.543

0.531

0.733

0.836

0.5

0.516

0.693

0.791

0.472

0.494

0.812

0.858

0.531

0.516

0.616

0.746

0.596

0.534

0.75

0.768

0.491

0.521

0.843

0.921

0.531

0.536

0.744

0.854

0.523

0.551

0.794

0.774

0.516

0.554

0.659

0.681

0.587

0.53

0.716

0.729

0.566

0.625

0.605

0.591

0.543

0.531

0.733

0.836

0.54

0.549

0.661

0.651

0.503

0.502

0.695

0.764

0.506

0.491

0.773

0.818

0.532

0.511

0.769

0.732

0.52

0.551

0.794

0.767

0.462

0.494

0.589

0.722

0.568

0.597

0.766

0.875

0.503

0.48

0.766

0.857

0.573

0.61

0.81

0.813

0.533

0.5

0.713

0.787

0.534

0.505

0.774

0.7

0.482

0.511

0.72

0.823

0.595

0.601

0.498

0.695

0.491

0.506

0.729

0.787

0.514

0.522

0.741

0.819

0.486

0.518

0.613

0.656

0.515

0.776

0.767

0.483

0.531

0.704

0.797

0.523

0.55

0.578

0.647

0.549

0.527

0.643

0.684

0.551

0.567

0.731

0.71

↓ **Table 3.** Intraclass Correlation Coefficients (ICC(2,1)) Between Two Raters for FA and ADC Measurements in Each ROI
	FA	ADC
ADC: apparent diffusion coefficient; CSDH: chronic subdural hematoma; FA: fractional anisotropy; ICC: intraclass correlation coefficient; ROI: region of interest.
CSDH pre-surgery	0.749	0.663	0.879	0.669
CSDH post-surgery	0.635	0.665	0.622	0.733
Putamen	0.683	0.787	0.863	0.712
Thalamus	0.692	0.805	0.815	0.919
Subcortical	0.799	0.743	0.924	0.761

↓ Table 3. Intraclass Correlation Coefficients (ICC(2,1)) Between Two Raters for FA and ADC Measurements in Each ROI

ADC

Lesion

Normal

Lesion

Normal

ADC: apparent diffusion coefficient; CSDH: chronic subdural hematoma; FA: fractional anisotropy; ICC: intraclass correlation coefficient; ROI: region of interest.

CSDH pre-surgery

0.749

0.663

0.879

0.669

CSDH post-surgery

0.635

0.665

0.622

0.733

Putamen

0.683

0.787

0.863

0.712

Thalamus

0.692

0.805

0.815

0.919

Subcortical

0.799

0.743

0.924

0.761

↓ **Table 4.** Multivariable Linear Regression Analysis for Factors Associated With FA Values
Model	Variable	Coefficient (β)	Standard error	P-value
ADC: apparent diffusion coefficient; CSDH: chronic subdural hematoma; FA: fractional anisotropy; ICH: intracerebral hemorrhage; mRS: modified Rankin scale.
Whole cohort	Group (CSDH vs. ICH)	0.030	0.016	0.071
	Age	6.46 × 10⁻⁶	0.0004	0.989
	Location (putamen/subcortical/thalamus)	0.010	0.008	0.207
	ADC	−0.017	0.061	0.783
	mRS at onset	0.0005	0.003	0.869
	mRS at discharge	0.001	0.004	0.742
ICH group	Hematoma volume	0.0002	0.0001	0.250
	Age	0.0001	0.0005	0.774
	Location (putamen/subcortical/thalamus)	0.010	0.007	0.141
	ADC	−0.048	0.078	0.540
	mRS at onset	−0.0003	0.003	0.923
	mRS at discharge	0.005	0.004	0.252

↓ Table 4. Multivariable Linear Regression Analysis for Factors Associated With FA Values

Model

Variable

Coefficient (β)

Standard error

P-value

ADC: apparent diffusion coefficient; CSDH: chronic subdural hematoma; FA: fractional anisotropy; ICH: intracerebral hemorrhage; mRS: modified Rankin scale.

Whole cohort

Group (CSDH vs. ICH)

0.030

0.016

0.071

Age

6.46 × 10⁻⁶

0.0004

0.989

Location (putamen/subcortical/thalamus)

0.010

0.008

0.207

ADC

−0.017

0.061

0.783

mRS at onset

0.0005

0.003

0.869

mRS at discharge

0.001

0.004

0.742

ICH group

Hematoma volume

0.0002

0.0001

0.250

Age

0.0001

0.0005

0.774

Location (putamen/subcortical/thalamus)

0.010

0.007

0.141

ADC

−0.048

0.078

0.540

mRS at onset

−0.0003

0.003

0.923

mRS at discharge

0.005

0.004

0.252