Figure 1. Axial brain MRI FLAIR sequences (a-c) and T2-weighted sequences (d-f) of the 64-year-old patient. Both axial MRI FLAIR and T2-weighted sequences of the patient demonstrate abnormal hyperintensities in the middle cerebellar peduncles (a, d), cerebral peduncles (b, e) and posterior limb of internal capsule (c, f). This type of leukodystrophy, affecting the white matter of the brain (including the internal capsule and cerebellar peduncles), is observed in patients with CLCN2-related leukoencephalopathy (CC2L). Thus, gene analysis was conducted and confirmed the diagnosis. MRI: magnetic resonance imaging; FLAIR: fluid-attenuated inversion recovery.